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Name Remodeling of Epithelial Adherens Junctions
Description The intercellular adherens junctions (AJ) are specialized sub-apical structures that function as principle mediators of cell-cell adhesion. Cadherins, the type-I transmembrane proteins of AJs, are principally responsible for homotypic cell-cell adhesion. The extracellular domain of E-cadherin binds calcium and forms complexes with the extracellular domains of E-cadherin molecules on neighboring cells. The cytoplasmic domain of E-cadherin associates with catenins, and provides anchorage to the actin cytoskeleton to form stable cell-cell contacts. Ctnn-? binds through its armadillo repeats to the distal region of the E-cadherin tail. Ctnn-? binds to Ctnn-? and links components of AJs to the actin cytoskeleton. It also
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