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Name Chondroitin and Dermatan Biosynthesis
Description General Background Chondroitin-sulfates Chondroitin and Dermatan-Sulfate dermatan are related sulfated Glycosaminoglycans. Chondroitin-sulfates Chondroitin is composed of alternating units of sulfated CPD-12557 and CPD-12521 residues, while in Dermatan-Sulfate dermatan the CPD-12521 residues have largely been converted to CPD-12515. The CPD-12557 residues are substituted to varying degrees with sulfate linked to 4- and/or 6-hydroxyl positions, forming CPD-12516 N-acetyl-?-D-galactosamine, CPD-12565 ?-N-acetyl-D-glucosamine or CPD-12526 N-acetyl-D-galactosamine, and to a lesser extent the uronic acid residues may be substituted with sulfate at the 2-hydroxyl position forming CPD-12527 or CPD-12518. The uronic acid residues may also be substituted with sulfate at the 3-hydroxyl positions, although this substitution
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