Heres a message for genes.
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Name ErbB4 Signaling
Description ErbB4 is a 180-kDa transmembrane RTK that regulates cell proliferation and differentiation. The ErbB4 gene has been isolated as the fourth member of the human EGFR subfamily of tyrosine kinases. Four structurally different ErbB4 isoforms have been identified. Ligands that bind to ErbB4 with high affinity and specificity and which provoke receptor activation and signaling are divided into two groups, the Neuregulin family (NRG, also termed Heregulins), and certain members of the EGF family of ligands. There are four NRG genes - 1, 2, 3, and 4, and the product of each is capable of recognizing ErbB4 in a biologically
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