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Name Neuroprotective Role of THOP1 in Alzheimer's Disease
Description Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which no efficacious treatments are available. The amyloid hypothesis postulates that amyloid ? (A?) deposits are the fundamental cause of the disease. The production of A? peptide by proteolytic cleavage of the amyloid precursor protein (APP) and mechanisms associated with A? clearance represent central determinants of A? levels in the brain. The imbalance in A? production and clearance is the primary cause of AD pathogenesis.Thimet oligopeptidase (THOP1) is a phosphoprotein that is expressed primarily in the brain, gonads and the pituitary gland. It is a 78 kDa metalloendopeptidase with a distinctive
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