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Name Endothelin-1 Signaling
Description Endothelin-1 (ET1) is a vasoconstrictor peptide that is able to induce cardiac hypertrophy. ET1 is the principal isoform in the cardiovascular system and remains the most ubiquitous, potent, and unusually long-lasting constrictor of blood vessels discovered. Biosynthesis of ET1 is primarily regulated by autocrine mechanisms and physico-chemical factors such as mechanical forces, changes in oxygen tension, changes in pH, angiotensin-II, vasopressin, norepinephrine, growth factors, cytokines, lipoproteins and adhesion molecules. Inhibitors of ET1 synthesis include nitric oxide (NO) and its intracellular effectors, cGMP, prostacyclin, atrial natriuretic peptides and steroid hormones. ET1 is also released from endothelial cell-specific storage granules (Weibel-Palade bodies)
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