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Name Melatonin Signaling
Description Melatonin is a hormone secreted mainly by the pineal gland or epiphysis, and in small quantity by the retina. Dissemination of circadian information relies on the activation of melatonin receptors, which are most prominently expressed in the suprachiasmatic nucleus (SCN), and the hypophyseal pars tuberalis, but also in many other tissues. Melatonin can activate or inhibit signal transduction cascades through receptors or independent of receptors. The hormone binds with high affinity in the picomolar range to its plasma membrane receptors, and/or in the nanomolar range to nuclear receptors (RZR/ROR), as well as to calmodulin. At higher concentrations, melatonin exhibits a
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