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Name NF-?B Activation by Viruses
Description Many viruses, including HIV1, HTLV1, HBV, HCV, EBV and Influenza virus activate NF-?B. The activation of NF-?B promotes viral replication, prevents virus-induced apoptosis, and mediates the immune response to the invading pathogen. NF-?B is normally found in the cytoplasm complexed with an inhibitory protein, I-?B. Upon infection, signaling events are initiated leading to activation of MEKK1, which is capable of phosphorylating I-?B. NF-?B then dissociates from phosphorylated I-?B and migrates to the nucleus where it activates transcription.NF-?B is constitutively activated in primary monocytes and myeloid cell lines chronically infected with HIV1. HIV1 infects CD4 T-lymphocytes through recognition of the CD4
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