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Name IL-8 Signaling
Description Interleukin 8 (IL-8) is a member of the C-X-C family of chemokines that plays a central role in angiogenesis, tumor growth and inflammation. The cell surface receptors for IL-8 which are coupled to G proteins include CXCR1 (IL-8 receptor type 1) and the CXCR2 (IL-8 receptor type 2). While the CXCR1 is selectively activated by IL-8 only, CXCR2 responds to several additional chemokines. The IL-8 receptors are expressed on several cell types like neutrophils, endothelial cells, monocytes and tumor cells.Angiogenesis is a multistep process including endothelial cell proliferation, migration, gap formation, capillary tube formation, endothelial cell survival and death. IL-8
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