Heres a message for genes.
Flash version 10.2+ is required to view Pathways.
Name Erythropoietin Signaling
Description Erythropoietin (Epo) elicits cell-specific responses upon interacting with its receptor EpoR. Activation of EpoR by Epo results in receptor homodimerization, which induces a cascade of signaling events.Epo is a major activator of the Ras/MAPK pathway. This activation is achieved via signaling through GRB2, SHC, GAB2 and the PTB domain containing proteins. GRB2 constitutively associates with SOS and binds to EpoR either via an interaction with GAB2 or by binding to EpoR-associated tyrosine-phosphorylated SHC. SHC recruits the GRB2-SOS complex to the plasma membrane, thereby promoting Ras activation. PKC, a potent activator of Ras and c-Raf, plays an important role in the
Copyright © 2021 QIAGEN Silicon Valley. All rights reserved.
Better Business Bureau