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Symbol STAT1
Name signal transducer and activator of transcription 1
Type transcription regulator
Synonyms 2010005J02Rik, AA408197, CANDF7, DD6G4-4, IMD31A, IMD31B, IMD31C, ISGF-3, p91, signal transducer and activator of transcription 1, Signal transducer and activator of transcription 1 alpha/beta, Signal transducer and activator of transcription 1 α/β, signal transducer and activator of transcription 1a, Similar to signal transducer and activator of transcription 1, STAT1, STAT1 alpha, Stat1 beta, Stat1 p91, STAT1 α, Stat1 β, stat1a, STAT91, TRANSCRIPTION FACTOR SIGNAL TRANSDUCER and ACTIVATOR, XStat1
Species Human (STAT1 EG:6772), Mouse (Stat1 EG:20846), Rat (Stat1 EG:25124), Cow (STAT1 EG:510814), Western Clawed Frog (stat1 EG:780397), Zebra Fish (stat1a EG:30768), Chicken (STAT1 EG:424044), Dog (STAT1 EG:488449)
SwissProt ID P42224, P42225
Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
STAT1 gene Interaction Network STAT1 gene Pathways
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Name STAT1 gene summary
Description Name: signal transducer and activator of transcription 1, Symbol: STAT1, Category: gene, Type: transcription regulator, Synonyms: 2010005J02Rik, AA408197, CANDF7, DD6G4-4, IMD31A, IMD31B, IMD31C, ISGF-3, p91, signal transducer and activator of transcription 1, Signal transducer and activator of transcription 1 alpha/beta, Signal transducer and activator of transcription 1 α/β, signal transducer and activator of transcription 1a, Similar to signal transducer and activator of transcription 1, STAT1, STAT1 alpha, Stat1 beta, Stat1 p91, STAT1 α, Stat1 β, stat1a, STAT91, TRANSCRIPTION FACTOR SIGNAL TRANSDUCER and ACTIVATOR, XStat1, Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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