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Symbol RAF1
Name Raf-1 proto-oncogene, serine/threonine kinase
Type kinase
Synonyms 6430402F14Rik, AA990557, BB129353, C-RAF, CMD1NN, Craf1, D830050J10Rik, leukaemiA ONCOGENE HOMOLOG1, LEUKEMIA ONCOGENE HOMOLOG1, NS5, Raf, Raf-1 proto-oncogene, serine/threonine kinase, Raf-1 proto-oncogene, serine/threonine kinase b, RAF1, raf1b, v-Raf, v-raf-leukaemia viral oncogene 1, v-raf-leukemia viral oncogene 1
Species Human (RAF1 EG:5894), Mouse (Raf1 EG:110157), Rat (Raf1 EG:24703), Cow (RAF1 EG:521196), Western Clawed Frog (raf1 EG:549871), Zebra Fish (raf1b EG:557109), Chicken (RAF1 EG:396245), Dog (RAF1 EG:484648)
SwissProt ID P04049, Q99N57, P11345, A7E3S4, P05625
Summary This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
RAF1 gene Interaction Network RAF1 gene Pathways
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Name RAF1 gene summary
Description Name: Raf-1 proto-oncogene, serine/threonine kinase, Symbol: RAF1, Category: gene, Type: kinase, Synonyms: 6430402F14Rik, AA990557, BB129353, C-RAF, CMD1NN, Craf1, D830050J10Rik, leukaemiA ONCOGENE HOMOLOG1, LEUKEMIA ONCOGENE HOMOLOG1, NS5, Raf, Raf-1 proto-oncogene, serine/threonine kinase, Raf-1 proto-oncogene, serine/threonine kinase b, RAF1, raf1b, v-Raf, v-raf-leukaemia viral oncogene 1, v-raf-leukemia viral oncogene 1, Summary: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
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