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Symbol MAPK8
Name mitogen-activated protein kinase 8
Type kinase
Synonyms AI849689, basket, bsk, Bsk1, C-JUN N-TERMINAL KINASE1, CG5680, D-junk, DBSK/JNK, Djnk, DJNK/bsk, Dmel CG5680, JNK, JNK-46, JNK/SAPK, JNK1, JNK1A2, JNK21B1/2, jun, Junk, MAPK8, mapk8a, mitogen-activated protein kinase 8, mitogen-activated protein kinase 8a, P-JNK, p46JNK1, p46JNK1 alpha, p46JNK1 α, PRKM8, Sapk gamma, SAPK P46, Sapk γ, SAPK1, SAPK1c, SAPKa, Stress activated protein kinase jnk, STRESS-ACTIVATED protein KINASE-LIKE KINASE, xJNK, zgc:172209
Species Human (MAPK8 EG:5599), Mouse (Mapk8 EG:26419), Rat (Mapk8 EG:116554), Cow (MAPK8 EG:539941), Fruit Fly (bsk EG:44801), Western Clawed Frog (mapk8 EG:100170194), Zebra Fish (mapk8a EG:562720), Dog (MAPK8 EG:477746)
SwissProt ID P45983, Q91Y86, P49185, P92208
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
MAPK8 gene Interaction Network MAPK8 gene Pathways
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Name MAPK8 gene summary
Description Name: mitogen-activated protein kinase 8, Symbol: MAPK8, Category: gene, Type: kinase, Synonyms: AI849689, basket, bsk, Bsk1, C-JUN N-TERMINAL KINASE1, CG5680, D-junk, DBSK/JNK, Djnk, DJNK/bsk, Dmel CG5680, JNK, JNK-46, JNK/SAPK, JNK1, JNK1A2, JNK21B1/2, jun, Junk, MAPK8, mapk8a, mitogen-activated protein kinase 8, mitogen-activated protein kinase 8a, P-JNK, p46JNK1, p46JNK1 alpha, p46JNK1 α, PRKM8, Sapk gamma, SAPK P46, Sapk γ, SAPK1, SAPK1c, SAPKa, Stress activated protein kinase jnk, STRESS-ACTIVATED protein KINASE-LIKE KINASE, xJNK, zgc:172209, Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
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