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Symbol MAPK1
Name mitogen-activated protein kinase 1
Type kinase
Synonyms 9030612K14Rik, AA407128, AU018647, BcDNA:RE08694, C78273, CG12559, CG18732, CT34260, CT39192, D-ERK, DERK-A, dm-dpERK, Dmel CG12559, DmErk, DmERK-A, DmMAPK, DpERK, dpERK1, dpMAPK, Dsor2, E(sina)7, EC2-1, EK2-1, ERK, ERK-2, ERK-A, Erk/Map kinase, Erk1, Erk1/2, ERK42, ERT1, EY2-2, GroupII, KSS1, l(2)41Ac, l(2R)EMS45-39, MAP-k, Mapk p42, MAPK1, Mapk1,2, mapk1-a, mapk1-b, MAPK2, MITOGEN ACTIVATED protein KINASE 2, mitogen-activated protein kinase 1, mitogen-activated serine/threonine-protein kinase KSS1, mpk1, p-ERK, p38, p40, p40 HERAK, p41, p41mapk, P42, p42 Erk, P42MAPK, pMAPK, PRKM1, PRKM2, rl, rl/ERK, rl/MAPK, rll, Rolled, SEM, SR2-1, Su(Raf)2B, xp42, YGR040W, zERK2
Species Human (MAPK1 EG:5594), Mouse (Mapk1 EG:26413), Rat (Mapk1 EG:116590), Baker's Yeast (KSS1 EG:852931), Cow (MAPK1 EG:327672), Fruit Fly (rl EG:3354888), Western Clawed Frog (mapk1 EG:549881), Zebra Fish (mapk1 EG:360144), Dog (MAPK1 EG:477575)
SwissProt ID P28482, P63085, P63086, P14681, P46196, P40417
Summary This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
MAPK1 gene Interaction Network MAPK1 gene Pathways
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Name MAPK1 gene summary
Description Name: mitogen-activated protein kinase 1, Symbol: MAPK1, Category: gene, Type: kinase, Synonyms: 9030612K14Rik, AA407128, AU018647, BcDNA:RE08694, C78273, CG12559, CG18732, CT34260, CT39192, D-ERK, DERK-A, dm-dpERK, Dmel CG12559, DmErk, DmERK-A, DmMAPK, DpERK, dpERK1, dpMAPK, Dsor2, E(sina)7, EC2-1, EK2-1, ERK, ERK-2, ERK-A, Erk/Map kinase, Erk1, Erk1/2, ERK42, ERT1, EY2-2, GroupII, KSS1, l(2)41Ac, l(2R)EMS45-39, MAP-k, Mapk p42, MAPK1, Mapk1,2, mapk1-a, mapk1-b, MAPK2, MITOGEN ACTIVATED protein KINASE 2, mitogen-activated protein kinase 1, mitogen-activated serine/threonine-protein kinase KSS1, mpk1, p-ERK, p38, p40, p40 HERAK, p41, p41mapk, P42, p42 Erk, P42MAPK, pMAPK, PRKM1, PRKM2, rl, rl/ERK, rl/MAPK, rll, Rolled, SEM, SR2-1, Su(Raf)2B, xp42, YGR040W, zERK2, Summary: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
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