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Symbol PRKCZ
Name protein kinase C zeta
Type kinase
Synonyms 14-3-3-zetaisoform, AI098070, aPKCzeta, aPKCζ, C80388, NPKC-ZETA, NPKC-ζ, PKC-ZETA, PKC-ζ, PKC2, Pkcz, PKMz, Prkc zeta, Prkc ζ, PRKCZ, protein kinase C zeta, protein kinase C ζ, protein kinase C, zeta, protein kinase C, ζ, r14-3-3, R74924, si:ch211-150o23.4, TPKC, zetaPKC
Species Human (PRKCZ EG:5590), Mouse (Prkcz EG:18762), Rat (Prkcz EG:25522), Cow (PRKCZ EG:286877), Western Clawed Frog (prkcz EG:100101769), Zebra Fish (prkcz EG:555737), Dog (PRKCZ EG:479577)
SwissProt ID Q05513, Q02956, P09217
Summary Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PRKCZ gene Interaction Network PRKCZ gene Pathways
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Name PRKCZ gene summary
Description Name: protein kinase C zeta, Symbol: PRKCZ, Category: gene, Type: kinase, Synonyms: 14-3-3-zetaisoform, AI098070, aPKCzeta, aPKCζ, C80388, NPKC-ZETA, NPKC-ζ, PKC-ZETA, PKC-ζ, PKC2, Pkcz, PKMz, Prkc zeta, Prkc ζ, PRKCZ, protein kinase C zeta, protein kinase C ζ, protein kinase C, zeta, protein kinase C, ζ, r14-3-3, R74924, si:ch211-150o23.4, TPKC, zetaPKC, Summary: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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