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Symbol ATM
Name ATM serine/threonine kinase
Type kinase
Synonyms AI256621, AT1, ATA, ataxia telangiectasia mutated, ATC, ATD, ATDC, ATE, ATM, ATM serine/threonine kinase, C030026E19RIK, LOC100331288, TEL1, TELO1, xatm
Species Human (ATM EG:472), Mouse (Atm EG:11920), Rat (Atm EG:300711), Western Clawed Frog (atm EG:100490767), Zebra Fish (atm EG:403064), Dog (ATM EG:479450)
SwissProt ID Q13315, Q62388
Summary The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
ATM gene Interaction Network ATM gene Pathways
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Name ATM gene interaction network
Description Name: ATM serine/threonine kinase, Symbol: ATM, Category: gene, Type: kinase, Synonyms: AI256621, AT1, ATA, ataxia telangiectasia mutated, ATC, ATD, ATDC, ATE, ATM, ATM serine/threonine kinase, C030026E19RIK, LOC100331288, TEL1, TELO1, xatm, Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
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