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Symbol HRAS
Name HRas proto-oncogene, GTPase
Type enzyme
Synonyms -Ha-ras Harvey rat sarcoma viral oncogene homolog b, C-BAS/HAS, C-H-RAS, C-HA-RAS, C-HA-RAS1, c-rasHa, CTLO, H-RASIDX, HA-RAS, HAMSV, Harvey rat sarcoma viral oncogene homolog, Harvey rat sarcoma virus oncogene, Harvey-ras, HRAS, HRas proto-oncogene, GTPase, HRAS1, hrasa, hrasb, hrasl, K-Ras, Kras2, LOC100151000, N-Ras, RAS, RAS HA, RASH1, sb:eu826, V-H-RAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog a, zgc:110250, zgc:110734
Species Human (HRAS EG:3265), Mouse (Hras EG:15461), Rat (Hras EG:293621), Western Clawed Frog (hras EG:549757), Zebra Fish (hrasa EG:550286), Zebra Fish (hrasb EG:553656)
SwissProt ID P01112, Q61411, P20171
Summary This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
HRAS gene Interaction Network HRAS gene Pathways
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Name HRAS gene summary
Description Name: HRas proto-oncogene, GTPase, Symbol: HRAS, Category: gene, Type: enzyme, Synonyms: -Ha-ras Harvey rat sarcoma viral oncogene homolog b, C-BAS/HAS, C-H-RAS, C-HA-RAS, C-HA-RAS1, c-rasHa, CTLO, H-RASIDX, HA-RAS, HAMSV, Harvey rat sarcoma viral oncogene homolog, Harvey rat sarcoma virus oncogene, Harvey-ras, HRAS, HRas proto-oncogene, GTPase, HRAS1, hrasa, hrasb, hrasl, K-Ras, Kras2, LOC100151000, N-Ras, RAS, RAS HA, RASH1, sb:eu826, V-H-RAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog a, zgc:110250, zgc:110734, Summary: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
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