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Symbol GRB2
Name growth factor receptor bound protein 2
Type kinase
Synonyms 24/1, AA408164, ASH, Ash-psi, CG6033, crkl, Dmel CG6033, downstream of receptor kinase, drk, Drk/Grb2, E(sev)2B, EGFRBP-GRB2, fb18e12, GRAB2, Grb/drk, GRB2, grb2-a, grb2-b, Grb2/drk, Grb3-3, growth factor receptor bound protein 2, growth factor receptor-bound protein 2b, l(2)10626, l(2)k13809, MST084, MSTP084, NCKAP2, P1112, Su(sev)R1, wu:fb18e12, wu:fb34e06, zgc:73077
Species Human (GRB2 EG:2885), Mouse (Grb2 EG:14784), Rat (Grb2 EG:81504), Cow (GRB2 EG:535298), Fruit Fly (drk EG:36497), Western Clawed Frog (grb2 EG:493492), Zebra Fish (grb2b EG:406308)
SwissProt ID P62993, Q60631, P62994, Q08012, Q66II3
Summary The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GRB2 gene Interaction Network GRB2 gene Pathways
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Name GRB2 gene summary
Description Name: growth factor receptor bound protein 2, Symbol: GRB2, Category: gene, Type: kinase, Synonyms: 24/1, AA408164, ASH, Ash-psi, CG6033, crkl, Dmel CG6033, downstream of receptor kinase, drk, Drk/Grb2, E(sev)2B, EGFRBP-GRB2, fb18e12, GRAB2, Grb/drk, GRB2, grb2-a, grb2-b, Grb2/drk, Grb3-3, growth factor receptor bound protein 2, growth factor receptor-bound protein 2b, l(2)10626, l(2)k13809, MST084, MSTP084, NCKAP2, P1112, Su(sev)R1, wu:fb18e12, wu:fb34e06, zgc:73077, Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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