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Symbol FGFR2
Name fibroblast growth factor receptor 2
Type kinase
Synonyms 0844/01, AU043015, AW556123, BBDS, BEK, BFR-1, breathless, btl, BTL/FGFR2, CD332, CEK3, CFD1, CG32134, CG6714, CT20816, D-FGFR, dev, DFGF-R1, DFR2, Dmel CG32134, DmHD-311, Dtk2, ECT1, fc56c05, FGFR, Fgfr-7, FGFR1, FGFR2, Fgfr2 3c, Fgfr2b, Fgfr2b isoform, Fgfr2c isoform, fibroblast growth factor receptor 2, HD-311, JWS, K-SAM, KGFR, KGFRTr, l(3)00208, l(3)j2E11, lambdatop, svs, TK14, Tk2, TK25, wu:fc56c05, xfgfr2
Species Human (FGFR2 EG:2263), Mouse (Fgfr2 EG:14183), Rat (Fgfr2 EG:25022), Cow (FGFR2 EG:404193), Fruit Fly (btl EG:39564), Western Clawed Frog (fgfr2 EG:100124910), Zebra Fish (fgfr2 EG:352940)
SwissProt ID P21802, P21803, Q09147, Q8JG38
Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
FGFR2 gene Interaction Network FGFR2 gene Pathways
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Name FGFR2 gene interaction network
Description Name: fibroblast growth factor receptor 2, Symbol: FGFR2, Category: gene, Type: kinase, Synonyms: 0844/01, AU043015, AW556123, BBDS, BEK, BFR-1, breathless, btl, BTL/FGFR2, CD332, CEK3, CFD1, CG32134, CG6714, CT20816, D-FGFR, dev, DFGF-R1, DFR2, Dmel CG32134, DmHD-311, Dtk2, ECT1, fc56c05, FGFR, Fgfr-7, FGFR1, FGFR2, Fgfr2 3c, Fgfr2b, Fgfr2b isoform, Fgfr2c isoform, fibroblast growth factor receptor 2, HD-311, JWS, K-SAM, KGFR, KGFRTr, l(3)00208, l(3)j2E11, lambdatop, svs, TK14, Tk2, TK25, wu:fc56c05, xfgfr2, Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
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