BETA
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FGFR1 gene Interaction Network
FGFR1 gene Pathways
| Symbol | FGFR1 |
| Name | fibroblast growth factor receptor 1 |
| Type | kinase |
| Synonyms | AW208770, bFGF-R-1, bFGF-R-1-A, BFGFR, c-fgr, cb231, CD331, CEK, Eask, ECCL, FGF receptor 1, FGFBR, FGFR-I, FGFR1, fgfr1-a, fgfr1-b, Fibroblast growth factor receptor 1, fibroblast growth factor receptor 1a, FLG, FLT-2, HBGFR, HH2, HRTFDS, Hspy, KAL2, MFR, N-SAM, OGD, sb:cb231, X1FGFR, XFGFR-1 |
| Species | Human (FGFR1 EG:2260), Mouse (Fgfr1 EG:14182), Rat (Fgfr1 EG:79114), Cow (FGFR1 EG:281768), Western Clawed Frog (fgfr1 EG:548648), Zebra Fish (fgfr1a EG:30705) |
| SwissProt ID | P11362, P16092, Q04589, Q90Z00 |
| Summary | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
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| Name | FGFR1 gene summary |
| Description | Name: fibroblast growth factor receptor 1, Symbol: FGFR1, Category: gene, Type: kinase, Synonyms: AW208770, bFGF-R-1, bFGF-R-1-A, BFGFR, c-fgr, cb231, CD331, CEK, Eask, ECCL, FGF receptor 1, FGFBR, FGFR-I, FGFR1, fgfr1-a, fgfr1-b, Fibroblast growth factor receptor 1, fibroblast growth factor receptor 1a, FLG, FLT-2, HBGFR, HH2, HRTFDS, Hspy, KAL2, MFR, N-SAM, OGD, sb:cb231, X1FGFR, XFGFR-1, Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
