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Symbol AKT1
Name AKT serine/threonine kinase 1
Type kinase
Synonyms AKT, AKT serine/threonine kinase 1, AKT1, akt2l, CWS6, LOC100331515, LOC101886355, LTR-akt, PKB, PKB-ALPHA, PKB-α, PKB/Akt, PRKBA, Protein kinase B, RAC, RAC-ALPHA, RAC-α, Thymoma proto-oncogene 1, thymoma viral proto-oncogene 1, v-akt, v-akt murine thymoma viral oncogene homolog 1, v-akt murine thymoma viral oncogene homolog 2, like, v-akt1, xAct
Species Human (AKT1 EG:207), Mouse (Akt1 EG:11651), Rat (Akt1 EG:24185), Cow (AKT1 EG:280991), Western Clawed Frog (akt1 EG:100490038), Zebra Fish (akt2l EG:403146), Zebra Fish (akt1 EG:101910198)
SwissProt ID P31749, P31750, P47196, Q01314
Summary The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
AKT1 gene Interaction Network AKT1 gene Pathways
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Name AKT1 gene pathways
Description Name: AKT serine/threonine kinase 1, Symbol: AKT1, Category: gene, Type: kinase, Synonyms: AKT, AKT serine/threonine kinase 1, AKT1, akt2l, CWS6, LOC100331515, LOC101886355, LTR-akt, PKB, PKB-ALPHA, PKB-α, PKB/Akt, PRKBA, Protein kinase B, RAC, RAC-ALPHA, RAC-α, Thymoma proto-oncogene 1, thymoma viral proto-oncogene 1, v-akt, v-akt murine thymoma viral oncogene homolog 1, v-akt murine thymoma viral oncogene homolog 2, like, v-akt1, xAct, Summary: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
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