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Symbol EGFR
Name epidermal growth factor receptor
Type kinase
Synonyms 9030024J15RIK, AI552599, C-ERBB, EGF receptor, EGF-TK, EGFR, EGFR vIII, EGFR1, EGFR12, EGFR15, egfra, epidermal growth factor receptor, epidermal growth factor receptor a (erythroblastic leukaemia viral (v-erb-b) oncogene homolog, avian), epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), ERBB, ERBB1, Errb1, Errp, HER-1 (EGFR), HER1, MENA, NISBD2, PIG61, wa-2, Wa5, XEgfr
Species Human (EGFR EG:1956), Mouse (Egfr EG:13649), Rat (Egfr EG:24329), Cow (EGFR EG:407217), Western Clawed Frog (egfr EG:100492965), Zebra Fish (egfra EG:378478), Dog (EGFR EG:404306)
SwissProt ID P00533, Q01279
Summary The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
EGFR gene Interaction Network EGFR gene Pathways
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Name EGFR gene summary
Description Name: epidermal growth factor receptor, Symbol: EGFR, Category: gene, Type: kinase, Synonyms: 9030024J15RIK, AI552599, C-ERBB, EGF receptor, EGF-TK, EGFR, EGFR vIII, EGFR1, EGFR12, EGFR15, egfra, epidermal growth factor receptor, epidermal growth factor receptor a (erythroblastic leukaemia viral (v-erb-b) oncogene homolog, avian), epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), ERBB, ERBB1, Errb1, Errp, HER-1 (EGFR), HER1, MENA, NISBD2, PIG61, wa-2, Wa5, XEgfr, Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
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