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Symbol MAPK14
Name mitogen-activated protein kinase 14
Type kinase
Synonyms 186F5S, anon-sts23, BG:DS00797.3, CG5475, CG7393, CRK1, CSBP, CSBP1, CSBP2, CSPB1, D-MPK2, D-p38, D-p38 MAPK, D-P38a, D-p38b, Dm p38b, Dmel CG5475, Dmel CG7393, DmMPK2, Dmp38a, ERK2, ESTS:186F5S, EXIP, fk28c03, group 2, hm:zeh1243, Hog, HOG1, LOC101929346, MAPK, MAPK p38, MAPK-2, MAPK14, mapk14a, mitogen-activated protein kinase 14, mitogen-activated protein kinase 14a, mitogen-activated protein kinase HOG1, MPK2, Mpk34C, Mxi2, P38, p38 beta, p38 kinase, P38 Map Kinase, p38 MAP kinases alpha and beta, p38 MAP kinases α and β, p38 MAPK, p38 MAPK-α, p38 β, p38-α, p38a, p38a MAP kinase, p38ALPHA, p38b, p38b MAP kinase, p38Hog, p38Ka, p38Kb, PRKM14, PRKM15, RK, SAPK p38 alpha, SAPK p38 α, sapk2, SAPK2A, SSK3, wu:fk28c03, YLR113W, zeh1243, zp38a
Species Human (MAPK14 EG:1432), Mouse (Mapk14 EG:26416), Rat (Mapk14 EG:81649), Baker's Yeast (HOG1 EG:850803), Cow (MAPK14 EG:534492), Fruit Fly (p38b EG:34780), Fruit Fly (p38a EG:42866), Western Clawed Frog (mapk14 EG:448296), Zebra Fish (mapk14a EG:65237), Dog (MAPK14 EG:403856)
SwissProt ID Q16539, P47811, P70618, P32485, O61443, O62618, Q9DGE2, O02812
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
MAPK14 gene Interaction Network MAPK14 gene Pathways
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Name MAPK14 gene summary
Description Name: mitogen-activated protein kinase 14, Symbol: MAPK14, Category: gene, Type: kinase, Synonyms: 186F5S, anon-sts23, BG:DS00797.3, CG5475, CG7393, CRK1, CSBP, CSBP1, CSBP2, CSPB1, D-MPK2, D-p38, D-p38 MAPK, D-P38a, D-p38b, Dm p38b, Dmel CG5475, Dmel CG7393, DmMPK2, Dmp38a, ERK2, ESTS:186F5S, EXIP, fk28c03, group 2, hm:zeh1243, Hog, HOG1, LOC101929346, MAPK, MAPK p38, MAPK-2, MAPK14, mapk14a, mitogen-activated protein kinase 14, mitogen-activated protein kinase 14a, mitogen-activated protein kinase HOG1, MPK2, Mpk34C, Mxi2, P38, p38 beta, p38 kinase, P38 Map Kinase, p38 MAP kinases alpha and beta, p38 MAP kinases α and β, p38 MAPK, p38 MAPK-α, p38 β, p38-α, p38a, p38a MAP kinase, p38ALPHA, p38b, p38b MAP kinase, p38Hog, p38Ka, p38Kb, PRKM14, PRKM15, RK, SAPK p38 alpha, SAPK p38 α, sapk2, SAPK2A, SSK3, wu:fk28c03, YLR113W, zeh1243, zp38a, Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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